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Depression in hepatitis B and C, and its correlation with hepatitis drugs consumption (interfron/lamivodin/ribaverin)

Shahriar Alian1, Abbas Masoudzadeh2, Talayeh Khoddad3

  • 1Department of infectious disease, Mazandaran university of Medical Science.

Iranian Journal of Psychiatry and Behavioral Sciences
|March 20, 2014
PubMed

Insights

Hepatitis B and C patients have high rates of depression, particularly those on interferon therapy. Regular depression screening is crucial for these individuals to improve their quality of life.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Psychiatry

Background:

  • Chronic hepatitis B and C infections are significant global health issues.
  • These viral infections can lead to severe liver dysfunction and reduced quality of life.
  • Depression is a common comorbidity, impacting patient well-being and potentially leading to adverse outcomes.

Purpose of the Study:

  • To determine the prevalence of depression in patients with hepatitis B and C.
  • To investigate the correlation between depression and hepatitis treatment medications.

Main Methods:

  • A cross-sectional study was conducted with 205 patients diagnosed with hepatitis B or C.
  • Depression was assessed using the Beck Depression Inventory (BDI).
  • Data were analyzed to identify correlations with hepatitis drug therapies.

Main Results:

  • Depression was highly prevalent: 68% in hepatitis B and 86% in hepatitis C patients.
  • The majority experienced moderate (57.3%) or severe (28.7%) depression.
  • Depression rates were highest in patients receiving interferon (100%) and interferon-ribavirin (94.4%) therapies.

Conclusions:

  • A significant burden of depression exists among hepatitis B and C patients.
  • Interferon therapy is strongly associated with increased depression prevalence.
  • Routine depression screening and management are recommended for these patients.
Abstract

Keywords:
Chronic Hepatitis BChronic Hepatitis CDepression Prevalence

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