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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
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Kidney Transplant I: Introduction01:28

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Kidney Transplant II: Surgical Procedure01:26

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Kidney Transplant III: Nursing Management01:16

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Updated: May 2, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
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Transplantation tolerance; myth or reality?

Aruna Vanikar1

  • 1G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India.

Journal of Nephropathology
|March 20, 2014
PubMed
Summary

Achieving transplant tolerance, where the body accepts a transplanted organ without lifelong immunosuppression, remains a critical goal. This editorial reviews progress toward this ideal state, which could significantly reduce transplant morbidity and graft loss.

Keywords:
End organ failureKidney transplantationRegulatory-T cellsStem cellsToleranceTransplantation

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Area of Science:

  • Transplantation immunology
  • Organ transplantation
  • Immunosuppression therapy

Background:

  • Organ transplantation is a standard therapy for end-stage organ failure.
  • Lifelong immunosuppression is necessary to prevent graft rejection but causes significant morbidity, including infections and malignancies.
  • Chronic graft attrition leads to graft loss within 7-10 years despite current strategies.

Purpose of the Study:

  • To review the progress made in achieving transplant tolerance.
  • To discuss the challenges and future directions in the pursuit of transplant tolerance.

Main Methods:

  • This is an editorial discussing the current state of research and clinical practice in transplant tolerance.
  • It synthesizes existing knowledge and expert opinion on the topic.

Main Results:

  • Transplant tolerance, defined as stable allograft function without immunosuppression and intact host immunity, is the ultimate goal.
  • Despite 60 years of research, true transplant tolerance remains elusive, often referred to as "Mackenna's gold."

Conclusions:

  • Significant progress has been made, but transplant tolerance is not yet a clinical reality.
  • Further research is crucial to overcome barriers and achieve a state of no immunosuppression in transplant recipients.
  • Achieving transplant tolerance promises to revolutionize organ transplantation by eliminating immunosuppression-related complications and improving long-term graft survival.