Using comparative effectiveness research to remedy health disparities

Health disparities are an important and continuing problem of considerable research importance. Comparative effectiveness research (CER) is an excellent vehicle to evaluate interventions to remedy disparities. We classify CER for disparities at three levels of science: basic biology, care and systems, and social and cultural context. In basic biology, genomics will delineate treatments for specific individuals and populations. Care and systems interventions are most important research areas to improve process and quality measures. However, there is evidence that correction of healthcare processes disparities will not be sufficient to improve health and that social and cultural research may be key in this regard. The methodology of CER for disparities is the same as that of other research with randomized controlled trials the gold standard and database analysis, and other observational and quasi-experimental methods important and effective. In addition, mixed methods and multilevel modeling offer promise. Community involvement in research and patient preferences among high-quality choices need to be included in planning of CER.