Intercellular adhesion molecule-1 polymorphisms in patients with Behçet disease: a meta-analysis

Area of Science:

• Genetics
• Immunology
• Rheumatology

Background:

• Behçet's disease is a rare, multisystemic inflammatory disorder of unknown etiology.
• Genetic factors are implicated in Behçet's disease pathogenesis.
• Intercellular adhesion molecule-1 (ICAM1) plays a role in immune cell trafficking and inflammation.

Purpose of the Study:

• To investigate the association between Intercellular adhesion molecule-1 (ICAM1) gene polymorphisms and Behçet's disease.
• To determine if specific ICAM1 genotypes are risk factors for developing Behçet's disease.

Main Methods:

• A systematic literature search was conducted in MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials up to July 31, 2012.
• Meta-analysis of pooled odds ratios (ORs) with 95% confidence intervals (CIs) was performed using fixed or random-effects models.
• Five relevant studies met the inclusion criteria for the meta-analysis.

Main Results:

• The ICAM1 E469 polymorphism (OR = 1.45, 95% CI = 1.06-1.97) and the ICAM1 469 E/E genotype (OR = 1.45, 95% CI = 1.09-1.94) were significantly associated with Behçet's disease.
• The ICAM1 241 G/R polymorphism demonstrated a strong association with Behçet's disease (OR = 3.65, 95% CI = 1.69-7.89).
• The ICAM1 469 E/E genotype was significantly associated with the presence of skin lesions in Behçet's disease patients (OR = 3.52, 95% CI = 1.62-7.66).

Conclusions:

• Behçet's disease is associated with specific ICAM1 polymorphisms (E469, 469 E/E, and 241 G/R) across different ethnic groups.
• The ICAM1 469 E/E genotype is particularly linked to the manifestation of skin lesions in Behçet's disease patients.