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Prevention of dicarbonyl-mediated advanced glycation by glyoxalases: implication in skin aging

Sabrina Radjei, Bertrand Friguet, Carine Nizard1

  • 1∥LVMH Recherche, 185 avenue de Verdun, 45800 Saint-Jean-de-Braye, France.

Biochemical Society Transactions
|March 21, 2014
PubMed

Insights

Skin aging involves protein damage from glycation, a process involving sugars and dicarbonyl compounds like glyoxal (GO) and methylglyoxal (MG). The glyoxalase system (Glo1 and Glo2) detoxifies these compounds, playing a role in skin health.

Area of Science:

  • Biochemistry
  • Dermatology
  • Molecular Biology

Background:

  • Skin aging results from intrinsic aging and photoaging, both causing histological and molecular changes, including protein alterations.
  • Glycation, a non-enzymatic reaction between reducing sugars and proteins, is a significant damage pathway in aging skin.
  • Dicarbonyl compounds, such as glyoxal (GO) and methylglyoxal (MG), are glucose derivatives that react with proteins, contributing to glycation.

Purpose of the Study:

  • To review the biological roles of the glyoxalase system enzymes (Glo1 and Glo2) in the context of aging.
  • To discuss the significance of glycation and its detoxification systems in human skin aging.

Main Methods:

  • Literature review of scientific articles on skin aging, glycation, and the glyoxalase system.
  • Analysis of the molecular mechanisms linking glycation, dicarbonyl compounds, and skin aging processes.

Main Results:

  • Glycation damages skin proteins, contributing to aging phenotypes.
  • The glyoxalase system, comprising glyoxalase I (Glo1) and glyoxalase II (Glo2), plays a crucial role in detoxifying harmful dicarbonyl compounds.
  • Dysregulation of the glyoxalase system may exacerbate age-related skin damage.

Conclusions:

  • Glycation is a key molecular mechanism implicated in both intrinsic and photoaging of the skin.
  • Understanding the glyoxalase system's role in detoxifying glycation-inducing compounds is vital for addressing skin aging.
  • Further research into glycation and the glyoxalase system could reveal new therapeutic targets for skin aging prevention and treatment.

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