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Exocrine pancreatic secretion in the elderly.

B Vellas¹, D Balas, J Moreau

¹Unite INSERM 151, CHU de Rangueil, Toulouse, France.

International Journal of Pancreatology : Official Journal of the International Association of Pancreatology

|December 1, 1988

Summary

Aging significantly impairs exocrine pancreatic function. Older adults show reduced bicarbonate and enzyme concentrations and output, impacting digestion and potentially nutritional status in the elderly.

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Area of Science:

Gastroenterology
Gerontology
Physiology

Background:

Exocrine pancreatic function is crucial for digestion.
Aging may lead to functional decline in various organs, including the pancreas.

Purpose of the Study:

To evaluate the impact of aging on exocrine pancreatic function.
To compare pancreatic secretion in young and elderly individuals.

Main Methods:

Studied 27 young (mean age 36) and 28 elderly (mean age 72) subjects without digestive disease.
Collected duodenal aspirates during secretin and caerulein infusion.
Measured bicarbonate and enzyme (lipase, chymotrypsin, amylase) concentrations and output.

Main Results:

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Elderly subjects had significantly reduced concentrations of bicarbonate (17%), lipase (15%), and chymotrypsin (23%).

Output levels of bicarbonate and enzymes were reduced by approximately 45% in the aged group.

These reductions were statistically significant (P < 0.05).

Conclusions:

Aging is associated with a marked functional involution of exocrine pancreatic secretion.
Reduced pancreatic function in the elderly may have implications for nutritional status.
Further research is needed to explore the clinical consequences of age-related pancreatic decline.