Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

1.8K
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
1.8K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.5K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K
Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

46
Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
46
Esophageal Achalasia01:27

Esophageal Achalasia

45
Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide...
45
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

2.1K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.1K
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

2.0K
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunoinflammatory Profile of FGF-18, IL-35 and Glutamic Acid Decarboxylase in Patients With Diabetic Foot Ulcers.

International wound journal·2026
Same author

Impact of age on the homing potential of <sup>89</sup>Zr-radiolabelled CD8 + T cells.

Scientific reports·2025
Same author

Biomarkers of type 2 and non-type 2 inflammation in asthma exacerbations.

Central-European journal of immunology·2024
Same author

Inflammatory disease status and response to TNF blockade are associated with mechanisms of endotoxin tolerance.

Journal of autoimmunity·2024
Same author

Metabolic requirements of Th17 cells and of B cells: Regulation and defects in health and in inflammatory diseases.

Frontiers in immunology·2022
Same author

Altered Nutrient Uptake Causes Mitochondrial Dysfunction in Senescent CD8<sup>+</sup> EMRA T Cells During Type 2 Diabetes.

Frontiers in aging·2022

Related Experiment Video

Updated: May 2, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.6K

Eosinophilic oesophagitis: clinical presentation and pathogenesis.

Jonas Bystrom1, Nuala R O'Shea

  • 1Bone and Joint Research Unit, William Harvey Research Institute, Barts & the London, Queen Mary University of London, , London, UK.

Postgraduate Medical Journal
|March 21, 2014
PubMed
Summary

Eosinophilic oesophagitis (EoE) is an underdiagnosed esophageal inflammation often linked to allergies. Understanding its immune response is key to developing better treatments beyond allergen elimination and corticosteroids.

Keywords:
HISTOPATHOLOGYIMMUNOLOGYPUBLIC HEALTH

More Related Videos

Surgical Models of Gastroesophageal Reflux with Mice
05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

10.1K
An Immunofluorescent Method for Characterization of Barrett&#8217;s Esophagus Cells
08:54

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

Published on: July 20, 2014

13.1K

Related Experiment Videos

Last Updated: May 2, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.6K
Surgical Models of Gastroesophageal Reflux with Mice
05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

10.1K
An Immunofluorescent Method for Characterization of Barrett&#8217;s Esophagus Cells
08:54

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

Published on: July 20, 2014

13.1K

Area of Science:

  • Gastroenterology
  • Immunology
  • Allergy

Background:

  • Eosinophilic oesophagitis (EoE) is an increasingly recognized esophageal inflammatory disorder.
  • Histologically defined by eosinophilic infiltration (>15 eosinophils/HPF), it presents with dysphagia and PPI-resistant dyspepsia.
  • EoE involves esophageal dysfunction, potential fibrosis, and remodeling, with allergic predispositions.

Purpose of the Study:

  • To review the current understanding of Eosinophilic oesophagitis (EoE) pathogenesis.
  • To highlight the immunological mechanisms underlying EoE.
  • To discuss current and emerging therapeutic strategies for EoE.

Main Methods:

  • Review of current literature on EoE.
  • Analysis of immunological and clinical aspects of EoE.
  • Evaluation of treatment strategies for EoE.

Main Results:

  • EoE pathogenesis involves a dysregulated immune response to environmental allergens (food in children, aeroallergens in adults).
  • The disease is characterized by a T helper type 2 (Th2) inflammatory response and esophageal remodeling.
  • Current treatments include allergen elimination and corticosteroids, but new targeted therapies are under investigation.

Conclusions:

  • A deeper understanding of EoE's underlying mechanisms is crucial for improving treatment options.
  • Targeting specific stages of EoE pathogenesis offers potential for novel therapies.
  • Further research into EoE pathophysiology will enhance therapeutic efficacy.