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Related Concept Videos

Pulmonary Tuberculosis II01:28

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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Related Experiment Video

Updated: May 2, 2026

Preparation of Mycobacterium Tuberculosis Culture Filtrate to Understand TB Pathogenesis
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Increased complement C1q level marks active disease in human tuberculosis.

Yi Cai1, Qianting Yang2, Yueqiang Tang2

  • 1Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China; Shenzhen Key Laboratory of Infection and Immunity, Shenzhen Third People's Hospital, Guangdong Medical College, Shenzhen, China.

Plos One
|March 21, 2014
PubMed
Summary
This summary is machine-generated.

Complement component C1q expression is elevated in active tuberculosis patients, correlating with disease severity. C1q shows potential as a diagnostic marker for distinguishing active tuberculosis from latent infection and pleurisy.

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Molecular Diagnostics

Background:

  • The complement system is crucial for host defense.
  • While C5 and C7 are linked to tuberculosis immunopathology, other complement components' roles remain unclear.

Purpose of the Study:

  • To investigate the role of complement component C1q in tuberculosis.
  • To evaluate C1q as a potential diagnostic biomarker for tuberculosis.

Main Methods:

  • Whole genome transcriptional microarray assays on peripheral blood mononuclear cells.
  • Validation of C1qA, C1qB, and C1qC mRNA and protein levels using qRT-PCR and ELISA.
  • Flow cytometry for C1q expression in CD14+ cells and C1qC quantification in pleural fluid.

Main Results:

  • C1q expression significantly increased in active tuberculosis patients' peripheral blood.
  • Elevated C1q expression correlated with sputum smear positivity and reduced post-chemotherapy.
  • C1qC mRNA and pleural fluid protein levels effectively discriminated active TB from latent TB and non-TB pleurisy.

Conclusions:

  • C1q expression is associated with active tuberculosis disease.
  • C1q demonstrates potential as a diagnostic marker for differentiating active TB, latent TB infection, and TB pleurisy.