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Humanized animal exercise model for clinical implication.

Dae Yun Seo1, Sung Ryul Lee, Nari Kim

  • 1National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Department of Health Sciences and Technology, Cardiovascular and Metabolic Disease Center, Inje University, Bok Ji-Ro 75, Busanjin-Gu, Busan, 613-735, Republic of Korea.

Pflugers Archiv : European Journal of Physiology
|March 21, 2014
PubMed
Summary
This summary is machine-generated.

Animal exercise models are crucial for developing treatments for chronic conditions like metabolic syndrome. This review summarizes aerobic and anaerobic models, highlighting factors influencing exercise outcomes.

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Area of Science:

  • Exercise physiology
  • Animal models in research

Background:

  • Exercise and physical activity are key in managing chronic conditions like metabolic syndrome and sarcopenia.
  • Animal models are essential for studying exercise interventions due to human research limitations.

Purpose of the Study:

  • To summarize current animal exercise models based on aerobic and anaerobic criteria.
  • To present specialized models for testing exercise effects on specific physiological conditions.
  • To offer considerations for developing new exercise model regimes.

Main Methods:

  • Review and summarization of existing literature on animal exercise models.
  • Categorization of models based on aerobic and anaerobic exercise types.
  • Inclusion of specialized models for targeted physiological studies.

Main Results:

  • Rodent models like treadmill running (aerobic) and ladder climbing (anaerobic) are commonly used.
  • No single 'golden standard' exercise protocol exists; type, timing, and duration are critical determinants.
  • Specialized models exist for investigating exercise's impact on specific health conditions.

Conclusions:

  • Understanding exercise physiology through animal models is vital for developing effective interventions.
  • Careful consideration of exercise parameters is necessary for optimizing health benefits.
  • This review provides a foundation for selecting and developing appropriate animal exercise models.