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Updated: May 2, 2026

Preparation and Use of Carbonyl-decorated Carbenes in the Activation of White Phosphorus
Published on: October 3, 2014
Carbon-carbon bond activation with 8-acylquinolines
Ashley M Dreis1, Christopher J Douglas
1Department of Chemistry, University of Minnesota, 207 Pleasant St. SE, Minneapolis, MN, 55455, USA.
Abstract:
Synthetically relevant advances in the area of carbon-carbon sigma bond activation have been made possible by 8-acylquinoline directing groups. Stable rhodium metallacycle intermediates have been shown to undergo a variety of transformations, including carboacylation reactions, to produce value-added products containing all-carbon quaternary centers. The kinetic profile of such reactions has been shown to be substrate dependent.
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