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Transcatheter aortic valve implantation (TAVI) offers a life-saving therapy for patients with aortic stenosis who are ineligible for surgery. Real-world registries show improved outcomes with TAVI due to increased operator experience and improved valve technology.

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Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Medical Technology

Background:

  • Aortic stenosis is increasing due to an aging population.
  • Conventional aortic valve replacement is not suitable for all symptomatic patients.
  • Transcatheter aortic valve implantation (TAVI) is established for high-risk and inoperable patients.

Purpose of the Study:

  • To review real-world data on TAVI outcomes from recent registries.
  • To assess the effectiveness of TAVI in a broader patient population beyond clinical trials.
  • To evaluate short- and midterm results of TAVI in daily clinical practice.

Main Methods:

  • Analysis of published Edwards SAPIEN and Medtronic CoreValve registries.
  • Inclusion of mixed national TAVI registries.
  • Focus on short- and midterm outcomes in real-world patient cohorts.

Main Results:

  • TAVI registries reflect real-world patient profiles, including comorbidities and anatomical challenges.
  • Improved operator experience and valve design contribute to better TAVI outcomes.
  • Short-term results of TAVI are improving in clinical practice.

Conclusions:

  • TAVI registries provide crucial evidence for treating high-risk aortic stenosis patients.
  • Further randomized trials in intermediate-risk patients are needed.
  • Long-term durability data is essential before expanding TAVI indications to lower-risk populations.