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Related Experiment Video

Updated: May 2, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

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Nimesulide/methyl β-cyclodextrin inclusion complexes: physicochemical characterization, solubility, dissolution, and

¹Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.

Drug Development Research

|March 21, 2014

Summary

Nimesulide (NIM), an insoluble anti-inflammatory drug, showed improved solubility and dissolution rates when complexed with methyl β-cyclodextrin. This complexation enhances NIM

Keywords:

anti-inflammatory effects formulation nimesulide β-cyclodextrin

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Published on: August 28, 2015

Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems
Materials Science

Background:

Nimesulide (NIM) is a poorly soluble nonsteroidal anti-inflammatory drug (NSAID).
Low solubility limits the therapeutic efficacy of many drugs, including NIM.
Developing strategies to enhance drug solubility is crucial for improving bioavailability.

Purpose of the Study:

To improve the solubility and dissolution rate of Nimesulide (NIM).
To investigate the complexation of NIM with methyl β-cyclodextrin (MβCD).
To characterize the physicochemical properties and evaluate the in vitro performance of NIM-MβCD inclusion complexes.

Main Methods:

Complexation of NIM with MβCD using a coevaporation technique at various molar ratios (1:1, 1:2, 1:3).
Physicochemical characterization using powder X-ray diffraction (PXRD) and infrared spectroscopy (IR).
Quantitative solubility and in vitro dissolution studies in phosphate buffer (pH 5.5 and 7.4).

Main Results:

Coevaporation successfully formed NIM-MβCD inclusion complexes.
PXRD and IR analyses indicated molecular interactions between NIM and MβCD.
Inclusion complexes significantly enhanced NIM solubility and dissolution rate compared to pure NIM.
Improved solubility and dissolution were observed at higher MβCD ratios.

Conclusions:

Methyl β-cyclodextrin complexation is an effective strategy to enhance the solubility and dissolution of Nimesulide.
The developed inclusion systems offer a promising approach for improving the delivery and therapeutic potential of Nimesulide.
The study confirms molecular interactions facilitating improved drug performance.