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Diabetes Mellitus: Type 2 and Gestational01:22

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Genetic Testing and Type 2 Diabetes Risk Awareness.

Mary de Groot1, Jennifer Wessel1,2

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Interest in genetic testing (GT) for type 2 diabetes (T2DM) varies by risk awareness. Younger age predicted interest in GT for those aware of their risk, while family history and desire to know genetic risk predicted interest for those unaware. Both groups need affordable GT options.

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Area of Science:

  • Genetics and genomics
  • Public health
  • Medical research

Background:

  • Type 2 diabetes mellitus (T2DM) is a significant public health concern.
  • Genetic testing (GT) offers a tool for predicting T2DM risk.
  • Understanding predictors of interest in GT is crucial for its effective implementation.

Purpose of the Study:

  • To investigate motivational, attitudinal, and behavioral factors influencing interest in genetic testing (GT) for type 2 diabetes (T2DM).
  • To compare these predictors between individuals aware and unaware of their T2DM risk.
  • To identify key determinants for engaging with genetic risk assessment for T2DM.

Main Methods:

  • Surveyed a convenience sample of 265 adults without diabetes but with T2DM risk factors.
  • Stratified participants based on awareness of their T2DM risk (risk aware vs. risk unaware).
  • Analyzed demographic, attitudinal, and behavioral variables predicting interest in GT.

Main Results:

  • 52% of participants expressed interest in GT for T2DM.
  • Among risk-aware individuals, younger age predicted greater GT interest.
  • Among risk-unaware individuals, family history of T2DM and a preference to know genetic risk predicted GT interest.
  • Both groups emphasized the need for low-cost genetic testing.

Conclusions:

  • Genetic testing is a relevant tool for T2DM risk prediction across different risk awareness levels.
  • Financial accessibility is a critical factor for the uptake of genetic testing for T2DM.
  • Tailoring genetic risk communication based on awareness levels may enhance engagement with T2DM prevention strategies.