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Related Concept Videos

Esophageal Perforation-I: Introduction01:22

Esophageal Perforation-I: Introduction

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Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
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Esophageal Perforation-II: Clinical Manifestations and Management01:28

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Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
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Esophagus01:24

Esophagus

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The esophagus, a muscular conduit linking the pharynx and stomach, measures roughly 10 inches (25.4 cm) and sits behind the trachea. It remains collapsed when not swallowing. The esophagus follows a predominantly straight path through the thoracic mediastinum and enters the abdominal cavity through a diaphragmatic opening known as the esophageal hiatus.
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Papillary Dermis01:11

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
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Peritoneum01:21

Peritoneum

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The peritoneum is a vital membrane that lines the abdominal cavity and covers most of the organs within it. It plays a crucial role in protecting the organs, providing a smooth surface for their movement, and facilitating various physiological processes. Understanding the anatomy and function of the peritoneum is essential for comprehending the complexities of the abdominal region.
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Appendicitis01:19

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Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
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Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
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Elastosis perforans serpiginosa.

Si-Hyung Lee1, Yuri Choi1, Soo-Chan Kim1

  • 1Department of Dermatology, Gangnam Severance Hospital, The Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Annals of Dermatology
|March 21, 2014
PubMed
Summary
This summary is machine-generated.

Elastosis perforans serpiginosa (EPS) is a rare skin condition. This case study highlights a patient with EPS unresponsive to standard treatments, including topical tretinoin.

Keywords:
Elastosis perforans serpiginosaTherapeutics

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Area of Science:

  • Dermatology
  • Pathology

Background:

  • Elastosis perforans serpiginosa (EPS) is a rare disorder of transepidermal elimination of abnormal elastic fibers.
  • EPS typically manifests as papules in annular or serpiginous patterns, often on the neck and flexural areas.
  • Current treatment options for EPS have limited efficacy.

Observation:

  • A 35-year-old male presented with a two-year history of refractory neck skin eruptions.
  • Clinical examination revealed annular erythematous papules with central clearing.
  • Histopathology showed transepidermal elimination of degenerated elastic fibers and nuclear debris.

Findings:

  • Verhoeff-van Gieson staining confirmed dense clumps of altered elastic fibers in the papillary dermis.
  • The patient was diagnosed with elastosis perforans serpiginosa.
  • Six months of topical 0.05% tretinoin treatment yielded no improvement.

Implications:

  • This case underscores the challenges in managing elastosis perforans serpiginosa.
  • The lack of response to tretinoin suggests limited therapeutic options for this rare condition.
  • Further research into effective treatments for EPS is warranted.