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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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The Tumor Microenvironment02:17

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Mesenchymal Stem Cells01:19

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Cancer Stem Cells and Tumor Maintenance02:40

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Stem Cell Niche01:26

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Updated: May 2, 2026

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
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Mesenchymal stem cells in the tumor microenvironment.

Jian Guan1, Jie Chen1

  • 1Department of Pathology, Peking Union Medical College Hospital, Beijing 100730, P.R. China.

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PubMed
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Mesenchymal stem cells (MSCs) can promote tumor growth by enhancing cancer stemness, migration, and angiogenesis. These cells also suppress immune responses and induce drug resistance, contributing to tumor progression.

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angiogenesischemotherapy resistanceimmunosuppressionmesenchymal stem cellmigrationstemnesstumor microenvironment

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Area of Science:

  • Oncology
  • Stem Cell Biology
  • Immunology

Background:

  • Mesenchymal stem cells (MSCs) are multipotent cells with migration capabilities.
  • MSCs are recruited to tumor microenvironments by chemokines and inflammatory factors.
  • Emerging evidence suggests MSCs play diverse roles in tumor development and progression.

Approach:

  • This study reviews existing literature on the pro-tumorigenic functions of MSCs.
  • The review examines MSC roles in enhancing tumor stemness, migration, and angiogenesis.
  • The study also investigates MSC-mediated immune suppression and drug resistance induction.

Key Points:

  • MSCs can increase the stemness of tumor cells.
  • MSCs contribute to tumor cell migration and angiogenesis.
  • MSCs suppress the anti-tumor immune response.
  • MSCs can induce resistance to cancer therapies.

Conclusions:

  • MSCs exhibit multifaceted tumor-promoting activities within the tumor microenvironment.
  • Understanding MSC roles is crucial for developing novel cancer therapies.
  • Targeting MSC functions may offer therapeutic strategies to combat cancer progression.