FAS-670 gene polymorphism and cervical carcinogenesis risk: A meta-analysis

FAS is a cell surface receptor that plays an important role in the etiology of cancer. Previous studies on the association between FAS-670 polymorphism and cervical carcinogenesis failed to reach a consensus; therefore, this meta-analysis was conducted to estimate the association of FAS-670 polymorphism and the risk of cervical cancer. This meta-analysis included 10 studies on FAS-670 genotyping, including a total of 2,901 cases and 2,831 controls. The complete overdominant model was applied in our meta-analysis [AB vs. AA: odds ratio (OR)=0.879, 95% confidence interval (CI): 0.775-0.998, P=0.046; BB vs. AA: OR=0.903, 95% CI: 0.775-1.052, P=0.190]. The random effects OR was 1.13 (95% CI: 0.95-1.34, I²=52.7%, P_{heterogeneity}=0.03). An ethnic subgroup analysis was subsequently performed. The OR for Asians was 1.25 (6 comparisons, 95% CI: 1.05-1.48, I²=23.5%, P_{heterogeneity}=0.03), whereas for Caucasians, no significant association was observed between FAS-670 polymorphism and cervical carcinogenesis (4 comparisons, OR=0.96, 95% CI: 0.75-1.24, I²=45.9%, P_{heterogeneity}=0.14).