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Updated: May 2, 2026
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
Published on: April 10, 2018
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Association between long non-coding RNA and human rare diseases (Review)
Jin-Hua He1, Ze-Ping Han1, Yu-Guang Li1
1Department of Laboratory, Central Hospital of Panyu District, Guangzhou, Guangdong 511400, P.R. China.
Biomedical Reports
|March 21, 2014
Summary
Long non-coding RNAs (lncRNAs) are key regulators in gene expression and development. These molecules play crucial roles in various biological processes and human diseases.
Area of Science:
- Molecular Biology
- Genetics
- Epigenetics
Background:
- Long non-coding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides.
- They share structural features with messenger RNAs (mRNAs) but lack conserved open reading frames.
- lncRNA expression is dynamic during differentiation and development, varying by tissue and time.
Purpose of the Study:
- To explore the functional roles of lncRNAs in biological processes.
- To investigate the involvement of lncRNAs in epigenetic regulation.
- To understand the contribution of lncRNAs to human rare diseases.
Main Methods:
- Analysis of lncRNA structure and characteristics.
- Examination of lncRNA expression patterns during differentiation and development.
- Investigation of lncRNA interactions with coding genes for epigenetic regulation.
Main Results:
- lncRNAs possess mRNA-like structural features but lack protein-coding potential.
- lncRNA expression is tightly regulated in a spatio-temporal manner.
- Evidence suggests lncRNAs are involved in epigenetic mechanisms affecting gene expression.
Conclusions:
- lncRNAs are significant regulatory molecules in cellular processes.
- Their dysregulation is implicated in the pathogenesis of human rare diseases.
- lncRNAs represent a promising area for understanding and potentially treating diseases.
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