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Updated: May 2, 2026

Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma
Published on: August 31, 2022
Tumor markers for hepatocellular carcinoma
Yan-Jie Zhao1, Qiang Ju1, Guan-Cheng Li1
1Tumor Immunobiology Laboratory of Cancer Research Institute, Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education, Key Laboratory of Carcinogenesis Ministry of Health, Central South University, Changsha, Hunan 410078, P.R. China.
Hepatocellular carcinoma (HCC) is a deadly cancer requiring early diagnosis. Current markers like alpha-fetoprotein (AFP) lack sufficient accuracy, necessitating the discovery of novel biomarkers for better liver cancer detection and treatment monitoring.
Area of Science:
- Oncology
- Biomarker Discovery
- Hepatocellular Carcinoma Research
Background:
- Hepatocellular carcinoma (HCC) presents a significant global health challenge, with high mortality rates and approximately one million cases annually.
- Despite its lethality, early diagnosis of HCC remains difficult, impacting patient survival rates.
- Current diagnostic methods, including alpha-fetoprotein (AFP) testing, iconography, and pathology, exhibit limitations in specificity and sensitivity for effective liver cancer screening.
Conclusions:
- Early diagnosis of hepatocellular carcinoma is crucial for improving patient survival.
- Novel molecular markers are essential to overcome the limitations of current HCC diagnostic methods.
- Further research into new biomarkers is required for effective early detection and therapeutic monitoring of liver cancer.
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