Related Experiment Videos
Epilepsy surgery in pediatric intractable epilepsy with destructive encephalopathy
So Young Park1, Hye Eun Kwon2, Hoon-Chul Kang1
1Department of Pediatric Neurology, Pediatric Epilepsy Clinics, Severance Children's Hospital, Epilepsy Research Institute, Yonsei University College of Medicine;
Journal of Epilepsy Research
|March 21, 2014
Summary
Epilepsy surgery effectively controlled seizures in children with destructive encephalopathy. Parents reported high satisfaction with surgical outcomes and improvements in their children's cognitive and behavior issues.
Area of Science:
- Pediatric Neurology
- Neurosurgery
- Epileptology
Background:
- Destructive encephalopathy often leads to medically intractable seizures in children.
- Epilepsy surgery is a potential treatment for severe cases unresponsive to medication.
Purpose of the Study:
- To review clinical features, surgical outcomes, and parental satisfaction in children with destructive encephalopathy undergoing epilepsy surgery.
- To evaluate the effectiveness of epilepsy surgery for intractable seizures in this population.
Main Methods:
- Retrospective review of 48 pediatric patients who underwent epilepsy surgery between October 2003 and August 2011.
- Assessment of functional outcomes and parental satisfaction at least 1 year post-surgery.
Main Results:
- Epileptic encephalopathy, including Lennox-Gastaut syndrome and infantile spasms, was common.
- Hypoxic ischemic injury was the leading etiology, followed by CNS infections and head trauma.
- 33.3% of patients achieved seizure freedom, and 87.5% of parents reported satisfaction with surgical outcomes. Even in non-seizure-free cases, 77.8% of parents were satisfied with cognitive and behavioral improvements.
Conclusions:
- Epilepsy surgery is an effective treatment for controlling seizures in children with destructive encephalopathy.
- Parental satisfaction extends beyond seizure control to encompass improvements in cognitive and behavioral aspects.
Related Concept Videos
01:24Epilepsy and Seizures: Overview
1.1K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.1K
01:13Seizures: Classification
1.2K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.2K
01:14Antiepileptic Drugs: Glutamate Antagonists
809
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
809