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Denigrins A-C: new antitubercular 3,4-diarylpyrrole alkaloids from Dendrilla nigra
Muthyala Murali Krishna Kumar1, Jarpula Devilal Naik, Kancherla Satyavathi
1a College of Pharmaceutical Sciences, Andhra University , Visakhapatnam 530003 , Andhra Pradesh , India.
Abstract:
Chemical diversity is vital to antitubercular drug discovery as it ensures a novel bioactivity profile. Marine sponges have so far provided more than 1000 new bioactive molecules. Ethyl acetate extract of the marine sponge Dendrilla nigra on bioactivity-guided screening yielded three new compounds denigrins A-C, with potent antitubercular activity. Spectral and chemical analyses confirmed that these three compounds belong to the 3,4-diaryl pyrrole alkaloid category. The presence of monohydroxy substitution on benzene rings is not very common in lamellarin and related 3,4-diaryl pyrrole alkaloids isolated from marine invertebrates. Among these, denigrin C showed highest potency (minimum inhibitory concentration 4 μg/mL) against Mycobacterium tuberculosis H37Rv.
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