Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

8.0K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
8.0K
The Extracellular Matrix01:29

The Extracellular Matrix

10.7K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
10.7K
The Extracellular Matrix01:42

The Extracellular Matrix

65.0K
Overview
65.0K
Extracellular Matrix01:26

Extracellular Matrix

5.9K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
5.9K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.7K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.7K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

8.0K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decreased expression of GPC1 in human skin keratinocytes and epidermis during ageing.

Experimental gerontology·2019
Same author

A competitive enzyme-linked immunosorbent assay for quantification of tetrastatin in body fluids and tumor extracts.

Analytical biochemistry·2015
Same author

Analytical methods for measuring collagen XIX in human cell cultures, tissue extracts, and biological fluids.

Analytical biochemistry·2013
Same author

Celebration of the 50th anniversary of the foundation of the French society for connective tissue research. Its short history in the frame of the origin and development of this discipline.

Pathologie-biologie·2012
Same author

17Beta-oestradiol up-regulates the expression of a functional UDP-glucose dehydrogenase in articular chondrocytes: comparison with effects of cytokines and growth factors.

Rheumatology (Oxford, England)·2008
Same author

[Role of matrikins in melanoma progression].

Annales pharmaceutiques francaises·2006
Same journal

Pathologie-biologie·2020
Same journal

Antibacterial and antibiofilm activities of Laurus nobilis L. essential oil against Staphylococcus aureus strains associated with oral infections.

Pathologie-biologie·2015
Same journal

[Not Available].

Pathologie-biologie·2015
Same journal

Oxidative damage and histopathological changes in lung of rat chronically exposed to nicotine alone or associated to ethanol.

Pathologie-biologie·2015
Same journal

Biological diagnosis of diabetes mellitus.

Pathologie-biologie·2015
Same journal

Association of CagPAI integrity with severeness of Helicobacter pylori infection in patients with gastritis.

Pathologie-biologie·2015
See all related articles

Related Experiment Video

Updated: May 2, 2026

Characterizing Cell Migration Within Three-dimensional In Vitro Wound Environments
06:10

Characterizing Cell Migration Within Three-dimensional In Vitro Wound Environments

Published on: August 16, 2017

7.1K

Extracellular matrix and wound healing.

F X Maquart1, J C Monboisse1

  • 1Laboratoire de biochimie et biologie moléculaire, CNRS FRE 3481, faculté de médecine, 51, rue Cognacq-Jay, CS 30018, 51095 Reims, France; Laboratoire central de biochimie, CHU de Reims, rue Serge-Kochman, 51092 Reims, France.

Pathologie-Biologie
|March 22, 2014
PubMed
Summary
This summary is machine-generated.

Extracellular matrix (ECM) components and their fragments, called matrikines, significantly influence cell functions crucial for skin wound repair. Understanding these ECM-cell interactions offers potential new therapeutic targets for healing defects.

Keywords:
CicatrisationCollagenCollagèneConnective tissue glycoproteinsElastinExtracellular matrixGlycoprotéines du tissu conjonctifGlycosaminoglycannesGlycosaminoglycansMatrice extracellulaireMatrikinesProteoglycansProtéoglycannesWound healingÉlastine

More Related Videos

Production of Extracellular Matrix Fibers via Sacrificial Hollow Fiber Membrane Cell Culture
06:01

Production of Extracellular Matrix Fibers via Sacrificial Hollow Fiber Membrane Cell Culture

Published on: February 2, 2019

7.0K
Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica
07:47

Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica

Published on: February 10, 2023

4.0K

Related Experiment Videos

Last Updated: May 2, 2026

Characterizing Cell Migration Within Three-dimensional In Vitro Wound Environments
06:10

Characterizing Cell Migration Within Three-dimensional In Vitro Wound Environments

Published on: August 16, 2017

7.1K
Production of Extracellular Matrix Fibers via Sacrificial Hollow Fiber Membrane Cell Culture
06:01

Production of Extracellular Matrix Fibers via Sacrificial Hollow Fiber Membrane Cell Culture

Published on: February 2, 2019

7.0K
Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica
07:47

Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica

Published on: February 10, 2023

4.0K

Area of Science:

  • Biochemistry
  • Cell Biology
  • Dermatology

Background:

  • The extracellular matrix (ECM) provides structural support to tissues.
  • Emerging evidence highlights ECM macromolecules' role in regulating vital cell functions like proliferation, migration, and apoptosis.
  • Specific ECM domains, termed 'matrikines,' also exhibit regulatory functions on cell activities.

Purpose of the Study:

  • To summarize findings on the effects of ECM macromolecules and matrikines on connective tissue and epithelial cells, particularly in skin.
  • To explore the implications of these interactions in the wound healing process.
  • To identify potential therapeutic targets for wound healing defects.

Main Methods:

  • Literature review and synthesis of existing research findings.
  • Analysis of studies investigating ECM components (collagens, elastin, glycosaminoglycans, proteoglycans, glycoproteins) and matrikines.
  • Focus on effects on skin connective tissue and epithelial cells.

Main Results:

  • ECM macromolecules and matrikines regulate critical cellular functions involved in tissue repair.
  • These molecules play a significant role in the complex process of wound healing.
  • Specific examples demonstrate the impact on connective tissue and epithelial cell behavior.

Conclusions:

  • ECM macromolecules and their derived matrikines are key regulators in wound healing.
  • A deeper understanding of ECM-cell signaling pathways can lead to novel therapeutic strategies.
  • Targeting ECM-cell interactions presents a promising avenue for treating impaired wound healing.