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In vivo 31P MRS in new antineoplastic agents evaluation on experimental tumor models
L Le Moyec1, S Naruse, T Higuchi
1Dept. of Neurosurgery, Kyoto Prefectural University of Medicine, Okasaki, Japan.
Cancer Biochemistry Biophysics
|July 1, 1988
Abstract:
Two new antineoplastic agents, a nitrosourea and a DNA-bis-intercalator have been studied in vivo by 31P magnetic resonance spectroscopy on a rat glioma and Walker carcinoma. On rat glioma, spectra are modified when the tumor is treated by the nitrosourea, showing the depletion of high-energy phosphates. On Walker carcinoma both drugs delay the tumor evolution to necrosis, showing important levels of high-energy phosphates on NMR spectra. There appears to be a great dependence upon energy metabolism during chemotherapy, depending on the nature and physiology of the observed tumor.