Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Delivery: Enteral Route

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...

Pharmaceutical Poisoning: Treatment Strategies

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Childhood trauma, substance use and mental health: Exploring differences across two Tunisian jails.

PloS one·2026

Same author

Observer agreement for a novel visual rating scale of vermian atrophy in childhood ataxia telangiectasia.

AJNR. American journal of neuroradiology·2026

Same author

How are handover delays from ambulances to emergency departments being addressed in the United Kingdom? A nationwide survey of ambulance services and emergency departments.

BMC emergency medicine·2026

Same author

Can Transesophageal Echocardiography-Guided CPR Improve Out-of-Hospital Cardiac Arrest Outcomes?

JAMA internal medicine·2026

Same author

Ethnic differences in injury mortality rates among adult emergency healthcare service users in high-income countries: a scoping review.

Health and social care delivery research·2026

Same author

Posterior Reversible Encephalopathy Syndrome (PRES) Following Fruquintinib in a Normotensive Patient With Metastatic Colorectal Cancer: A Case Report.

Cureus·2025

Search research articles

Related Experiment Video

Updated: May 2, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Paramedic-supplied 'Take Home' Naloxone: protocol for cluster randomised feasibility study.

Chris Moore¹, Gregory Lloyd, Rossana Oretti

¹Medical and Clinical Services Directorate, Welsh Ambulance Services NHS Trust, Blackweir Ambulance Station, Cardiff, UK.

|March 22, 2014

Summary

Paramedics can distribute

Keywords:

Accident & Emergency Medicine Public Health

More Related Videos

Experimental Human Pneumococcal Carriage

Experimental Human Pneumococcal Carriage

Published on: February 15, 2013

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

Related Experiment Videos

Last Updated: May 2, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Experimental Human Pneumococcal Carriage

Experimental Human Pneumococcal Carriage

Published on: February 15, 2013

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

Area of Science:

Public Health
Emergency Medicine
Addiction Research

Background:

Traditional distribution of Take Home Naloxone (THN) kits via drug services may not reach high-risk individuals.
Paramedic attendance at overdose calls offers a novel opportunity for THN kit distribution.
Feasibility of paramedic-led THN distribution requires evaluation.

Purpose of the Study:

To assess the acceptability of paramedic-led distribution of Take Home Naloxone (THN) kits.
To gather data for planning a definitive trial on paramedic-administered THN.
To evaluate the feasibility of reaching at-risk populations through emergency medical services.

Main Methods:

Cluster randomized trial with staggered allocation of paramedics.
Intervention group: paramedics trained and issued THN kits.
Control group: paramedics follow usual practice until trained.
Data collection on patient eligibility, THN offer/acceptance, ED attendance, overdose recurrence, mortality, and follow-up rates.
Qualitative data on acceptability via interviews and focus groups with patients and paramedics.

Main Results:

Feasibility study data collection in progress.
Qualitative data on acceptability to be gathered.
Quantitative data on process and outcome measures to inform trial planning.

Conclusions:

Paramedic-led THN distribution is a potentially viable strategy to increase access to life-saving overdose reversal medication.
Further research is needed to confirm the effectiveness and optimize the implementation of this intervention.
This approach could significantly impact overdose prevention efforts within emergency medical services.