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TCTP as therapeutic target in cancers

Julie Acunzo1, Virginie Baylot1, Alan So2

  • 1(a)Inserm, U1068, CRCM, Marseille F-13009, France; (b)Institut Paoli-Calmettes, Marseille F-13009, France; (c)Aix-Marseille Univ., Marseille F-13284, France; (d)CNRS, UMR7258, Marseille F-13009, France.

Cancer Treatment Reviews
|March 22, 2014
PubMed

Insights

The translationally controlled tumor protein (TCTP) is a key regulator in cell functions and cancer. This review explores TCTP

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • The translationally controlled tumor protein (TCTP) is a highly conserved eukaryotic protein.
  • TCTP is localized in both cytoplasm and nucleus, with expression varying across tissues and responding to extracellular stimuli.
  • It interacts with itself and other proteins like MCL1 and p53, influencing critical cellular processes.

Purpose of the Study:

  • To review the pathways regulated by TCTP.
  • To discuss current strategies for inhibiting TCTP in cancer treatment.

Main Methods:

  • Literature review of TCTP's role in cellular functions and disease.
  • Analysis of TCTP's involvement in physiological and stress responses.
  • Examination of TCTP's association with malignancy and chemoresistance.

Main Results:

  • TCTP is implicated in cell proliferation, cell death, immune responses, stress response, and tumor reversion.
  • Elevated TCTP expression correlates with increased malignancy and chemoresistance.
  • TCTP's multifaceted roles highlight its significance in cancer biology.

Conclusions:

  • TCTP is a critical protein involved in fundamental cellular processes and cancer development.
  • Targeting TCTP presents a promising therapeutic strategy for various cancerous diseases.
  • Further research into TCTP-regulated pathways and inhibition methods is warranted.
Keywords:
CancerInhibitory strategyTCTPTherapeutic target

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