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Related Experiment Videos

Adenosine induces dormancy in starfish blastulae.

N Tsuchimori1, S Miyashiro, H Shibai

  • 1Department of Applied Biochemistry, Hiroshima University, Japan.

Development (Cambridge, England)
|June 1, 1988
PubMed
Summary

Adenosine application halts starfish embryo development by inhibiting macromolecular synthesis. Reversal of these effects occurs when the embryo is returned to normal seawater, allowing development to resume.

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Immunological Survey of Planktonic Embryos and Larvae of the Starfish Asterina pectinifera, Obtained from the Sea, Using a Monoclonal Antibody Directed against Egg Polypeptides.

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Area of Science:

  • Developmental Biology
  • Marine Biology
  • Biochemistry

Background:

  • Adenosine is a key signaling molecule in biological systems.
  • Embryonic development relies on precise regulation of macromolecular synthesis.

Purpose of the Study:

  • To investigate the effect of external adenosine on early starfish development.
  • To understand the impact of adenosine on macromolecular synthesis during embryogenesis.

Main Methods:

  • Starfish embryos (Asterina pectinifera) were treated with external adenosine.
  • Intracellular adenosine and nucleotide levels were measured.
  • Rates of protein, DNA, and RNA synthesis were quantified.

Main Results:

  • External adenosine application inhibited development at the 256-cell stage.
  • Intracellular adenosine levels increased significantly without altering ATP, ADP, or AMP concentrations.
  • Macromolecular synthesis (protein, DNA, RNA) was reduced by over 95%.

Conclusions:

  • Adenosine significantly disrupts starfish embryonic development by inhibiting macromolecular synthesis.
  • The observed effects are reversible upon removal of exogenous adenosine, suggesting a regulatory role.

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