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A decrease in spatially resolved near-infrared spectroscopy-determined frontal lobe tissue oxygenation by

Shigehiko Ogoh1, Kohei Sato, Kazunobu Okazaki

  • 1From the *Department of Biomedical Engineering, Toyo University, Kawagoe-Shi, Saitama; †Research Institute of Physical Fitness, Japan Women's College of Physical Education, Tokyo; ‡Department of Environmental Physiology for Exercise, Osaka City University Graduate School of Medicine; §Faculty of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Japan; ‖Department of Anesthesia, The Copenhagen Muscle Research Center, University of Copenhagen, Copenhagen, Denmark; and ¶Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.

Anesthesia and Analgesia
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Summary
This summary is machine-generated.

Phenylephrine reduces frontal lobe tissue oxygenation (ScO2) by causing extracranial vasoconstriction, not by affecting cerebral blood flow. This study used near-infrared spectroscopy and ultrasound to measure blood flow changes.

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Area of Science:

  • Physiology
  • Neuroscience
  • Medical Imaging

Background:

  • Frontal lobe tissue oxygenation (ScO2), measured by near-infrared spectroscopy, decreases with phenylephrine administration.
  • Cerebral blood flow may remain unaffected during phenylephrine infusion.
  • Extracranial vasoconstriction is hypothesized to explain the observed decrease in ScO2.

Purpose of the Study:

  • To investigate whether phenylephrine-induced changes in frontal lobe ScO2 are due to extracranial vasoconstriction.
  • To examine the relationship between ScO2, arterial blood pressure, and blood flow in extracranial and cerebral vessels.

Main Methods:

  • Seven healthy volunteers (25 ± 4 years) underwent measurements of ScO2, internal and external carotid artery blood flow, and vertebral artery blood flow using duplex ultrasonography.
  • Middle cerebral artery mean blood velocity, forehead skin blood flow, and mean arterial blood pressure were also monitored.
  • Intravenous infusion of phenylephrine was administered during the measurements.

Main Results:

  • Phenylephrine infusion increased mean arterial blood pressure and decreased ScO2 by -19% ± 3% (P = 0.0005).
  • External carotid artery blood flow (-27.5% ± 3.0%) and forehead skin blood flow (-25.4% ± 7.8%) significantly decreased.
  • Significant correlations were found between ScO2 and forehead skin blood flow (Spearman r = 0.81, P < 0.001) and external carotid artery conductance (Spearman r = 0.64, P = 0.012).

Conclusions:

  • Phenylephrine administration leads to a decrease in frontal lobe ScO2.
  • This decrease in ScO2 is primarily attributed to vasoconstriction in the extracranial vasculature.
  • The findings suggest that near-infrared spectroscopy measurements of ScO2 during phenylephrine infusion reflect extracranial, not cerebral, oxygenation changes.