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The chick chorioallantoic membrane assay: an improved technique for the study of angiogenic activity
M J Peek1, T M Norman, C Morgan
1Department of Obstetrics and Gynaecology, University of Sydney, New South Wales, Australia.
Experimental Pathology
|January 1, 1988
Abstract:
The chick chorioallantoic membrane assay has been used for many years as an in vivo assay of angiogenic activity. However it has been plagued with the problem of a high incidence of false positive angiogenic responses. In this study the conventional chick chorioallantoic membrane assay was compared with a modification of this technique in a series of batches using a total of 100 eggs. False positive reactions were recorded in 32 out of 50 (64%) using the conventional method and only 11 out of 50 (22%) with the modified method (chi 2 = 17.992; p less than 0.001).