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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Updated: May 2, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
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Mesenchymal stem cells for chronic wounds therapy.

Peter Zahorec1, Jan Koller, Lubos Danisovic

  • 1Department of Burns and Reconstructive Surgery, Faculty of Medicine, Comenius University in Bratislava, Pazitkova 4, 821 01, Bratislava, Slovakia.

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Summary

Mesenchymal stem cells (MSCs) offer a promising therapeutic strategy for chronic wounds, a serious medical problem unresponsive to conventional treatments. This review explores MSCs

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Area of Science:

  • Regenerative Medicine
  • Tissue Engineering
  • Wound Healing Research

Background:

  • Chronic non-healing wounds pose significant morbidity and mortality risks.
  • Conventional therapies like dermal substitutes and growth factors often fail.
  • Alternative strategies are crucial for complete wound closure and patient recovery.

Purpose of the Study:

  • To review current preclinical data on Mesenchymal Stem Cells (MSCs).
  • To summarize MSCs' biological characteristics and mechanisms in healing.
  • To outline their clinical applications in treating chronic wounds.

Main Methods:

  • Literature review of preclinical and clinical studies on MSCs.
  • Analysis of MSCs' role in tissue regeneration and wound repair.
  • Synthesis of information on MSCs' therapeutic potential.

Main Results:

  • MSCs possess unique biological properties beneficial for tissue regeneration.
  • Preclinical and clinical studies indicate MSCs' efficacy in healing acute and chronic wounds.
  • MSCs show potential in scar remodeling and improving wound closure outcomes.

Conclusions:

  • Mesenchymal Stem Cells (MSCs) represent a promising therapeutic approach for chronic wound management.
  • Their regenerative capabilities offer an alternative to conventional treatments.
  • Further research and clinical application of MSCs are warranted for improved patient outcomes.