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Updated: May 2, 2026

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
Published on: June 11, 2019
Imaging findings of acute intravascular thrombus on non-enhanced computed tomography
Ryan T Whitesell1, Scott D Steenburg
1Department of Radiology and Imaging Sciences, Indiana University Health Methodist Hospital, 1701 N. Senate Blvd, Room AG-176, Indianapolis, IN, 46202, USA.
Insights
Acute intravascular thrombosis can be detected on non-contrast CT scans. The "hyperdense vessel sign" indicates increased clot density, aiding diagnosis in various body regions and prompting further imaging.
Area of Science:
- Radiology
- Medical Imaging
Background:
- Intravascular thrombosis and thromboembolism are critical diagnoses.
- Contrast-enhanced computed tomography (CECT) and Doppler ultrasound are common diagnostic tools.
- Non-contrast CT (NECT) is sometimes used for acute intravascular pathology.
Purpose of the Study:
- To review the appearance of acute intravascular thrombosis on NECT.
- To highlight the utility of the "hyperdense vessel sign" on NECT.
Main Methods:
- Pictorial review of NECT scans.
- Focus on the hyperdense vessel sign in acute thrombosis.
Main Results:
- Acute thrombus appears hyperdense (increased Hounsfield unit density) on NECT compared to the blood pool.
- This sign is applicable to arterial and venous thrombosis in the chest, abdomen, pelvis, and extremities, not just stroke.
- NECT can suggest or aid in the diagnosis of intravascular thrombosis.
Conclusions:
- The hyperdense vessel sign on NECT is a valuable indicator of acute intravascular thrombosis.
- NECT can be a useful initial imaging modality for suspected thrombosis, guiding further diagnostic workup.
Abstract:
Intravascular thrombosis and thromboembolism are critical diagnoses which are frequently made on contrast-enhanced computed tomography (CECT) or Doppler ultrasound. For a variety of reasons, some patients with acute intravascular pathology are imaged using CT without intravenous contrast. In the acute setting, the increased Hounsfield unit (HU) density of the thrombus compared to the blood pool allows the diagnosis to be made, or at least suggested, on non-enhanced computed tomography (NECT). The increased density of the clot is commonly referred to as the "hyperdense vessel sign." This is a well-known finding in the setting of stroke, but hyperdense vessels can also signal arterial or venous thrombosis in the chest, abdomen, pelvis, and extremities. Once a hyperdense vessel sign is noted on NECT, further exploration with CECT, angiography, or ultrasound may then be performed. Here, we present a pictorial review of the appearance of acute intravascular thrombosis as seen on non-enhanced computed tomography.
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