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Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Related Experiment Video

Updated: May 2, 2026

Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection
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Extra-pulmonary tuberculosis: a biomarker analysis.

J Fortún1, P Martín-Dávila, E Gómez-Mampaso

  • 1Infectious Diseases Department, Ramon y Cajal Hospital, Ctra Colmenar km 9.1, 28034, Madrid, Spain, fortunabete@gmail.com.

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|March 22, 2014
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Summary
This summary is machine-generated.

Extra-pulmonary tuberculosis (EPTB) diagnosis is challenging. Mannose-binding lectin (MBL) shows potential as a biomarker distinguishing EPTB from pulmonary tuberculosis (PTB).

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Area of Science:

  • Infectious Diseases
  • Immunology
  • Biochemistry

Background:

  • Biomarker research for tuberculosis (TB) predominantly focuses on pulmonary TB (PTB).
  • Limited data exists on reliable biomarkers for extra-pulmonary TB (EPTB), hindering accurate diagnosis and management.
  • This study investigates novel biomarkers for differentiating EPTB from PTB.

Purpose of the Study:

  • To identify and evaluate serum biomarkers capable of distinguishing between PTB and EPTB.
  • To assess the diagnostic potential of specific biomarkers, including mannose-binding lectin (MBL), for EPTB.
  • To compare biomarker levels in PTB, EPTB, and healthy controls.

Main Methods:

  • Serum samples were collected from 24 PTB patients, 29 EPTB patients, and 27 healthy controls.
  • Levels of interferon-gamma, chemokine ligand 9, mannose-binding lectin (MBL), Ca-125, and adenosine deaminase were measured.
  • Receiver Operating Characteristic (ROC) curve analysis was performed for MBL serum levels.

Main Results:

  • All tested biomarkers were significantly elevated in both PTB and EPTB patients compared to controls.
  • Mannose-binding lectin (MBL) serum levels were significantly higher in EPTB patients than in PTB patients (p=0.01).
  • ROC analysis for MBL demonstrated an AUC of 0.85 for differentiating EPTB from non-EPTB, with optimal cut-off at 1,000 μg/ml (79.3% sensitivity, 78.0% specificity).

Conclusions:

  • Most investigated biomarkers function as acute phase reactants and cannot differentiate between pulmonary and extra-pulmonary TB.
  • Mannose-binding lectin (MBL) emerges as a potential exception, showing promise in distinguishing EPTB from PTB.
  • MBL may serve as a valuable diagnostic biomarker for EPTB, aiding in clinical decision-making.