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Use of a new water-soluble Zn sensor to determine Zn affinity for the amyloid-β peptide and relevant mutants
Sabrina Noël1, Susana Bustos Rodriguez, Stéphanie Sayen
1CNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse Cedex 4, France.
Metallomics : Integrated Biometal Science
|March 22, 2014
Abstract:
Evaluation of Zn affinity for the amyloid-β peptide involved in Alzheimer's disease and its modified counterparts is reported. This was made possible by the use of a new water-soluble chelator, the properties of which have also been described. Changes in the peptide sequence that impact Zn affinity are briefly discussed.
