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Association between SRC-1 gene polymorphisms and coronary artery aneurysms formation in Taiwanese children with

Yng-Tay Chen1, Wen-Lin Liao, Ying-Ju Lin

  • 1Human Genetic Center, China Medical University Hospital, Taichung, Taiwan.

Journal of Clinical Laboratory Analysis
|March 22, 2014
PubMed

Insights

Steroid receptor coactivator-1 (SRC-1) gene variations may contribute to coronary artery aneurysms (CAA) in Kawasaki disease (KD) patients. Further research into these SRC-1 polymorphisms is recommended to understand CAA development.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Pediatric Cardiology

Background:

  • Kawasaki disease (KD) can lead to coronary artery aneurysms (CAA), increasing the risk of ischemic heart disease and sudden death.
  • The exact causes of CAA in KD patients remain largely unknown.
  • Investigating genetic factors is crucial for understanding CAA pathogenesis in KD.

Purpose of the Study:

  • To explore the association between steroid receptor coactivator-1 (SRC-1) gene polymorphisms and the development of coronary artery aneurysms (CAA) in patients with Kawasaki disease (KD).
  • To identify potential genetic markers for CAA susceptibility in KD.

Main Methods:

  • Genotyping of four SRC-1 single nucleotide polymorphisms (SNPs) (rs11894248, rs17791703, rs7572475, rs9309308) was performed.
  • Analysis included 327 Taiwanese individuals: 279 KD patients without CAA and 48 KD patients with CAA.
  • The study also examined the Smad3 gene polymorphism (rs12901071) for comparison.

Main Results:

  • Statistically significant differences in genotype and allele frequencies of the studied SRC-1 SNPs were observed between KD patients with and without CAA (P < 0.01).
  • No statistically significant association was found for the Smad3 gene polymorphism (rs12901071) with CAA in KD patients.
  • These findings suggest a potential role for SRC-1 gene variations in CAA development.

Conclusions:

  • SRC-1 gene polymorphisms are implicated as potential contributors to the pathogenesis of coronary artery aneurysms in Kawasaki disease.
  • The specific SRC-1 polymorphisms investigated warrant further investigation for their role in CAA.
  • Understanding these genetic links could inform future diagnostic or therapeutic strategies for KD complications.
Abstract

Keywords:
Kawasaki disease (KD)coronary artery aneurysm (CAA)steroid receptor coactivator-1 (SRC-1)

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