Related Experiment Video

Updated: May 2, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
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Published on: June 28, 2019

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Fractional flow reserve: an updated review

Islam Y Elgendy1, C Richard Conti, Anthony A Bavry

  • 1Department of Medicine, University of Florida College of Medicine, Gainesville, Florida.

Clinical Cardiology
|March 22, 2014
PubMed

Insights

Fractional flow reserve (FFR) helps identify significant coronary artery blockages. This invasive measurement guides revascularization decisions, improving patient management when noninvasive tests are inconclusive.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Physiology

Background:

  • Coronary artery disease management often involves revascularization.
  • Conventional angiography can overestimate lesion severity, leading to unnecessary interventions.
  • Accurate assessment of coronary physiology is crucial for optimal treatment.

Purpose of the Study:

  • To review the concept and clinical utility of Fractional Flow Reserve (FFR).
  • To discuss the evidence supporting FFR in guiding revascularization decisions.
  • To explore future perspectives for FFR application in coronary artery disease.

Main Methods:

  • Review of current literature on Fractional Flow Reserve (FFR).
  • Analysis of studies comparing FFR diagnostic accuracy with noninvasive modalities.
  • Examination of clinical outcome data from studies using FFR-guided treatment strategies.

Main Results:

  • FFR is a valuable tool for assessing the hemodynamic significance of coronary lesions.
  • European Society of Cardiology guidelines recommend FFR for guiding revascularization when noninvasive data is lacking.
  • FFR-guided strategies have demonstrated clinical utility in managing intermediate coronary stenoses.

Conclusions:

  • FFR provides critical physiological information beyond anatomical assessment.
  • Accurate FFR measurement aids in selecting appropriate patients for revascularization.
  • Further research will continue to refine the role of FFR in interventional cardiology.

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