Related Experiment Video
Updated: May 2, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
Virulence and pathogenesis of HIV-1 infection: an evolutionary perspective
Christophe Fraser1, Katrina Lythgoe1, Gabriel E Leventhal2
1Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, UK.
Abstract:
Why some individuals develop AIDS rapidly whereas others remain healthy without treatment for many years remains a central question of HIV research. An evolutionary perspective reveals an apparent conflict between two levels of selection on the virus. On the one hand, there is rapid evolution of the virus in the host, and on the other, new observations indicate the existence of virus factors that affect the virulence of infection whose influence persists over years in infected individuals and across transmission events. Here, we review recent evidence that shows that viral genetic factors play a larger role in modulating disease severity than anticipated. We propose conceptual models that reconcile adaptive evolution at both levels of selection. Evolutionary analysis provides new insight into HIV pathogenesis.
More Related Videos
14:23A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
Published on: August 31, 2014
13:13Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques
Published on: September 25, 2018
Related Concept Videos
Viral Mutations
Retroviruses
Size and Structure of Viral Genomes
Introduction to Virus
Retrovirus Life Cycles
Evolution of New Traits in Microbes