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Experimental study on the inhibitory effect of sodium cantharidinate on human hepatoma HepG2 cells
Shi-Qi Wen1, Quan Chen1, Ming Hu1
1Department of Vascular, Gansu Provincial Hospital, Lanzhou 730000, China.
Background:
[corrected] Cantharidin, and its derivatives can not only inhibit the proliferation of tumor cells, but can also induce tumor cell apoptosis. It shows cantharidin exhibits a wide range of reactivity in anticancer. The objective of this paper was to study the inhibitory effect of sodium cantharidinate on human hepatoma HepG2 cells.
Materials And Methods:
MTT assay was used to detect the proliferation of HepG2 cells, and immunohisto-chemical method was used to detect the change in VEGF, protein level, and to determine the inhibitory effect of sodium cantharidinate on human hepatoma HepG2 cells.
Results:
As results, sodium cantharidinate significantly inhibited the growth of HepG2 cells in a time-and dose-dependent manner.
Conclusion:
We conclude that sodium cantharidinate has an inhibitory effect on human hepatoma HepG2 cells.
