Matrix Metalloprotienases and its inhibitors: An insight

Periodontal disease progression involves degradation of the collagenous matrix by a group of enzymes known as the matrix metalloprotienases. These matrix metalloprotienases are secreted by the polymorphonuclear leukocytes, macrophages, fibroblasts, bone, epithelial and endothelial cells. These molecules have involvement in both physiological and pathological processes. It is shown that periodontal disease occurs when there is an imbalance between the activated metalloprotienases and their endogenous inhibitors. These can be modified by exogenous inhibitors like bisphosphonates, tetracyclines, etc. How to cite the article: Kumar P, Kumar L, Murthy S, Gurudath G. Matrix Metalloprotienases and its inhibitors: An insight. J Int Oral Health 2014;6(1):127-9.