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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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An algorithm for glaucoma screening in clinical settings and its preliminary performance profile.

S-Farzad Mohammadi1, Sara Mirhadi1, Hadi Z Mehrjardi2

  • 1Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Journal of Ophthalmic & Vision Research
|March 22, 2014
PubMed
Summary

A new glaucoma screening algorithm effectively identifies new cases in clinical settings. The protocol demonstrated applicability and effectiveness, aiding in early glaucoma detection among asymptomatic individuals.

Keywords:
Chronic GlaucomaClinical Setting ScreeningGlaucoma ScreeningScreening AlgorithmScreening Test Performance

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Area of Science:

  • Ophthalmology
  • Public Health
  • Medical Diagnostics

Background:

  • Glaucoma is a leading cause of irreversible blindness worldwide.
  • Early detection and intervention are crucial for managing glaucoma and preventing vision loss.
  • Effective screening tools are needed for clinical implementation.

Purpose of the Study:

  • To develop and assess a glaucoma screening algorithm for clinical use.
  • To evaluate the algorithm's performance in identifying glaucoma cases.

Main Methods:

  • The screening protocol involved optic disc examination, Goldmann applanation tonometry, and automated perimetry.
  • Retinal nerve fiber layer imaging using scanning laser polarimetry was used in the diagnostic phase.
  • The algorithm was evaluated in an eye hospital-based program with 124 participants aged 40+.

Main Results:

  • Glaucoma was diagnosed in 4.8% of participants, with five new cases identified.
  • The positive predictive value of the screening protocol was 30%.
  • The screening protocol successfully excluded 80% of the initial population.

Conclusions:

  • A structured glaucoma screening algorithm can aid in detecting new glaucoma cases in clinical settings.
  • The developed algorithm showed practical applicability and effectiveness in identifying glaucoma in asymptomatic individuals.