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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Drug Dosing: Geriatric Patients01:15

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Related Experiment Video

Updated: May 2, 2026

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans
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Aging.

Dong Choon Park1, Seung Geun Yeo2

  • 1Department of Obstetrics and Gynecology, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.

Korean Journal of Audiology
|March 22, 2014
PubMed
Summary

Aging mechanisms involve genetic and environmental factors, leading to physiological decline. This review explores key aging theories and interventions like diet and exercise for longevity.

Area of Science:

  • Gerontology
  • Molecular Biology
  • Physiology

Background:

  • Aging is a complex biological process influenced by genetic and environmental factors from birth.
  • It manifests as reduced cell counts, tissue deterioration, decreased metabolism, and altered body fluid balance.
  • Despite extensive research, the precise mechanisms and progression of aging remain incompletely understood.

Purpose of the Study:

  • To review prominent theories explaining the aging process.
  • To discuss established and emerging concepts in aging research.
  • To highlight practical interventions influencing aging.

Main Methods:

  • Literature review of aging theories.
  • Synthesis of current understanding of aging mechanisms.
Keywords:
AgingPathological agingPhysiological phenomena

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  • Discussion of evidence-based lifestyle interventions.

    • Main Results:

    • Key theories include genetic programming, wear-and-tear, telomere shortening, and DNA damage.
    • Other significant theories involve endocrine changes, error catastrophe, metabolic rate, mitochondria, and free radicals.
    • Diet, exercise, and caloric restriction show promise in mitigating aging processes.

    Conclusions:

    • Aging is multifactorial, involving a combination of genetic predispositions and environmental exposures.
    • Understanding diverse aging theories is crucial for developing effective longevity strategies.
    • Lifestyle interventions like diet and exercise offer tangible approaches to promote healthy aging.