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Parameter optimization for applying the prepulse gap paradigm to humans.

Myung-Whan Suh1, Kun Woo Kim2, Il-Yong Park3

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea.

Korean Journal of Audiology
|March 22, 2014
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Summary
This summary is machine-generated.

This study optimized a tinnitus detection method using auditory stimuli in humans. The best results for inhibiting startle responses were achieved with a 20-millisecond gap before a 1 kHz pulse noise.

Keywords:
Cortical responseInhibitionN1-P2ObjectivePrepulse gapTinnitus

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Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Tinnitus Research

Background:

  • Tinnitus detection in animals can be achieved using a specific auditory stimulus.
  • This stimulus involves background noise matched to tinnitus pitch and a louder pulse noise.
  • The prepulse inhibition of the startle reflex differs between normal and tinnitus-affected subjects.

Purpose of the Study:

  • To optimize an auditory stimulation paradigm for detecting tinnitus in human subjects.
  • To maximize the prepulse inhibition of the N1-P2 amplitude in normal human participants.

Main Methods:

  • Seven normal hearing subjects without tinnitus were recruited.
  • Auditory stimuli included background noise and pulse noise, with and without a 50 msec silent gap.
  • The N1-P2 cortical response amplitude was measured under gap and no-gap conditions.

Main Results:

  • The smallest prepulse inhibition to noise (G/N) ratio occurred with a 20 msec gap.
  • Optimal inhibition was observed without a Hanning window.
  • An optimal background noise intensity of 20 dB SL yielded significant N1-P2 amplitude reduction.

Conclusions:

  • The optimal stimulus for tinnitus detection involves 1 kHz pulse noise without a Hanning window.
  • A background noise intensity of 20 dB HL and a 20 msec gap are recommended.
  • These parameters are expected to yield approximately 78.0% inhibition of N1-P2 amplitude in non-tinnitus subjects.