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Updated: Jul 31, 2026
Method for Obtaining Primary Ovarian Cancer Cells From Solid Specimens
Published on: February 4, 2014
Evaluation of primary prophylaxis with granulocyte colony-stimulating factor for epithelial ovarian cancer
Purpose:
Primary prophylaxis with G-CSF has been used to minimize myelosuppression caused by anticancer agents and to avoid severe neutropenia. The authors retrospectively examined the value of primary prophylaxis using granulocyte colony-stimulating factor (G-CSF) for epithelial ovarian cancer.
Materials And Methods:
From 2001 to 2010, 105 patients with ovarian cancer receiving chemotherapy in the present hospital were divided into two groups: one received primary prophylaxis with G-CSF and the other did not receive it in compliance with the guidelines for G-CSF usage. The incidence of febrile neutropenia (FN), degree of neutropenia, frequency of G-CSF administration, number of days of hospitalization, progression-free survival (PFS), and overall survival (OS) were evaluated.
Results:
Neutrophils decreased almost equally and the length of hospitalization was not significantly lower between the groups. Five-year PFS or OS showed no significant difference either.
Conclusions:
Primary prophylaxis with G-CSF in chemotherapy for epithelial ovarian cancer could be of low significance.
