Related Experiment Video

Updated: May 1, 2026

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
09:59

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

Published on: July 21, 2023

2.1K

Salmonella subtypes with increased MICs for azithromycin in travelers returned to The Netherlands

Robert-Jan Hassing, Wil H F Goessens, Wilfrid van Pelt

    Emerging Infectious Diseases
    |March 25, 2014
    PubMed

    Insights

    Antimicrobial resistance in typhoidal Salmonella is a growing concern. Azithromycin resistance was observed in some Salmonella isolates, potentially complicating the treatment of enteric fever.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Typhoidal Salmonella infections remain a significant global health issue.
    • Antimicrobial resistance is a critical challenge in managing enteric fever.
    • Monitoring resistance patterns is essential for effective treatment strategies.

    Purpose of the Study:

    • To analyze antimicrobial susceptibility patterns of typhoidal Salmonella isolates.
    • To determine the prevalence of azithromycin resistance in relation to ciprofloxacin resistance.
    • To assess the implications of observed resistance for empirical treatment.

    Main Methods:

    • Analysis of antimicrobial susceptibility testing data.
    • Collection of 354 typhoidal Salmonella isolates from 1999-2012 in the Netherlands.
    • Determination of minimum inhibitory concentrations (MICs) for key antimicrobial agents.

    Main Results:

    • 16.1% of all isolates exhibited increased azithromycin minimum inhibitory concentrations (MICs).
    • Among isolates with increased ciprofloxacin MICs, 23.8% also showed increased azithromycin MICs.
    • A concerning prevalence of resistance was noted, particularly in conjunction with ciprofloxacin resistance.

    Conclusions:

    • The emergence of azithromycin resistance in typhoidal Salmonella is a significant finding.
    • This resistance pattern may compromise the effectiveness of azithromycin as a treatment option.
    • Healthcare providers should be aware of these resistance trends when initiating empirical therapy for enteric fever.
    Keywords:
    Salmonellaazithromycinbacteriacephalosporindrug resistanceenteric feverfluoroquinoloneparatyphithe Netherlandstravel medicinetyphityphoid

    More Related Videos

    An Allelotyping PCR for Identifying Salmonella enterica serovars Enteritidis, Hadar, Heidelberg, and Typhimurium12:18

    An Allelotyping PCR for Identifying Salmonella enterica serovars Enteritidis, Hadar, Heidelberg, and Typhimurium

    Published on: July 22, 2011

    24.2K
    A High-throughput Platform for the Screening of Salmonella spp./Shigella spp.06:55

    A High-throughput Platform for the Screening of Salmonella spp./Shigella spp.

    Published on: November 7, 2018

    7.9K

    Related Concept Videos

    Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

    Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

    Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
    602
    Clinical Significance of Antibiotic Resistance01:25

    Clinical Significance of Antibiotic Resistance

    Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
    90
    Fungal Phylum Microsporidia01:28

    Fungal Phylum Microsporidia

    Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
    782