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Interaction of hexachlorocyclohexane (HCH) and chlorpropham (CIPC) in male rats
T S Dikshith1, G Carrera, R B Raizada
1Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
Toxicology Letters
|February 1, 1989
Abstract:
Hexachlorocyclohexane (60.0 mg/kg/d) and chlorpropham (50.0 mg/kg/d) given to male rats daily orally for 30 d caused subtle biochemical lesions. The significant rise in the activity of alkaline phosphatase in liver and serum and of GOT and GPT in liver with substantial weight increase of liver has been suggestive of the initiation of biochemical lesions and adaptation of the organism. Very severe hepatocellular damage is forecasted if the pesticides are given for a prolonged period and in higher concentrations to animals.