Long-term coagulation changes after resection of thoracoabdominal malignancies

Area of Science:

• Oncology
• Hematology
• Surgical Research

Background:

• Malignancy resection can impact patient coagulation status.
• Long-term monitoring of hemostasis in cancer patients is crucial.
• Understanding postoperative coagulation changes is vital for patient management.

Purpose of the Study:

• To evaluate the long-term coagulation status in patients after malignancy resection.
• To assess the utility of rotational thromboelastography (ROTEM) in monitoring hemostasis.
• To identify potential biomarkers for predicting venous thromboembolism (VTE) risk.

Main Methods:

• Prospective observational trial with 52 thoracoabdominal tumor patients.
• Coagulation assessed using rotational thromboelastography (ROTEM) and plasma hemostatic markers.
• 6- to 12-month follow-up for coagulation status evaluation.

Main Results:

• Postoperative hypercoagulability, indicated by increased Maximum Clot Firmness (MCF), normalized by 9.2 months.
• Elevated markers of thrombin generation, fibrinolysis, and endothelial activation were observed.
• ROTEM patterns varied with tumor histology and location; 6% of patients developed VTE.

Conclusions:

• Point-of-care ROTEM can identify cancer patients at risk for VTE.
• Ongoing prothrombotic state confirmed by functional hemostasis markers.
• Cancer-induced hypercoagulability reversal varies by tumor type and location.