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NLRC3 puts the brakes on STING
Matthew S J Mangan1, Eicke Latz2
1Institute of Innate Immunity, University Hospitals, Biomedical Centre, University of Bonn, 53127 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.
Abstract:
NOD-like receptors (NLRs) are increasingly implicated in regulating pathogen-sensing pathways. In this issue of Immunity, Zhang et al. (2014) describe a role for NLRC3 in regulating STING and the inflammatory response to cytosolic DNA.
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