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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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T Cell Types and Functions01:24

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Cytotoxic T Cells-mediated Immune Response01:27

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Antigen Presenting Cells01:22

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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
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Cells of the Adaptive Immune Response01:23

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Related Experiment Video

Updated: May 1, 2026

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
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An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

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Dendritic cells decide CD8(+) T cell fate.

Allan McI Mowat1

  • 1Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Sir Graeme Davies Building, Glasgow G12 8TA, Scotland, UK.

Immunity
|March 25, 2014
PubMed
Summary

CD103-positive dendritic cells (DCs) in mouse lungs bind the alarmin HMGB1 using CD24. This interaction selectively generates effector CD8(+) T cells by presenting HMGB1 to RAGE-positive T cells.

Area of Science:

  • Immunology
  • Cell Biology
  • T cell differentiation

Background:

  • Dendritic cells (DCs) play a crucial role in initiating adaptive immune responses.
  • CD8(+) T cells are critical for cell-mediated immunity, including anti-viral and anti-tumor responses.
  • The specific mechanisms by which lung DCs generate effector CD8(+) T cells are not fully elucidated.

Purpose of the Study:

  • To investigate the role of CD103(+) DCs in the mouse lung in generating effector CD8(+) T cells.
  • To identify the molecular interactions involved in this DC-T cell communication.

Main Methods:

  • The study utilized mouse models to examine dendritic cell populations in the lung.
  • Immunohistochemistry and flow cytometry were employed to identify cell populations and molecular markers.

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  • Functional assays were performed to assess T cell activation and differentiation.

    • Main Results:

    • CD103(+) DCs in the mouse lung were found to selectively generate effector CD8(+) T cells.
    • These DCs bind the alarmin HMGB1 via the CD24 molecule.
    • The interaction involves presenting HMGB1 to RAGE-expressing T cells, leading to T cell activation.

    Conclusions:

    • CD103(+) DCs in the lung utilize a specific pathway involving HMGB1 and CD24 to induce effector CD8(+) T cell responses.
    • This mechanism highlights a novel role for alarmin presentation by DCs in shaping adaptive immunity in the lung.