Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 1, 2026

Inducing Dendritic Growth in Cultured Sympathetic Neurons
09:52

Inducing Dendritic Growth in Cultured Sympathetic Neurons

Published on: March 21, 2012

12.6K

Active dendrites under parental supervision.

Thomas G Oertner1

  • 1Institute for Synaptic Physiology, Center for Molecular Neurobiology Hamburg, Falkenried 94, 20251 Hamburg, Germany.

Neuron
|March 25, 2014
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrastructural analysis of synapses after induction of spike-timing-dependent plasticity.

Cell reports methods·2025
Same author

Interfacing with the Brain: How Nanotechnology Can Contribute.

ACS nano·2025
Same author

Changes in Neuroimmunological Synapses During Cerebral Ischemia.

Translational stroke research·2024
Same author

Optical Control of G-Actin with a Photoswitchable Latrunculin.

Journal of the American Chemical Society·2024
Same author

Optical Control of G-Actin with a Photoswitchable Latrunculin.

bioRxiv : the preprint server for biology·2023
Same author

ΔFosB accumulation in hippocampal granule cells drives cFos pattern separation during spatial learning.

Nature communications·2022
Same journal

Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses.

Neuron·2026
Same journal

Sparse component analysis: A method that uncovers separable computations within neural population activity.

Neuron·2026
Same journal

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Neuron·2026
Same journal

TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging.

Neuron·2026
Same journal

Image space opens up for visual neuroscience.

Neuron·2026
Same journal

Septal GLP-1 receptors control alcohol taking and seeking.

Neuron·2026
See all related articles

Pyramidal cell dendrites in the hippocampus generate active calcium signals. This study explores their function in live mice, moving beyond brain slice experiments.

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Calcium Signaling

Background:

  • Pyramidal cell dendrites exhibit active calcium signaling in brain slices.
  • Understanding dendritic function in vivo is crucial for comprehending neural circuit operations.

Purpose of the Study:

  • To investigate the functional properties of dendritic calcium signals in hippocampal pyramidal neurons of live mice.
  • To characterize the diversity and spatial distribution of active dendritic calcium signals in vivo.

Main Methods:

  • In vivo two-photon calcium imaging in the hippocampus of awake, head-fixed mice.
  • Recording dendritic activity from CA1 pyramidal neurons.
  • Analysis of calcium transients and their relationship to neuronal activity.

More Related Videos

Time-lapse Live Imaging and Quantification of Fast Dendritic Branch Dynamics in Developing Drosophila Neurons
08:23

Time-lapse Live Imaging and Quantification of Fast Dendritic Branch Dynamics in Developing Drosophila Neurons

Published on: September 25, 2019

5.8K
Imaging Dendritic Spines in Caenorhabditis elegans
09:14

Imaging Dendritic Spines in Caenorhabditis elegans

Published on: September 27, 2021

2.3K

Related Experiment Videos

Last Updated: May 1, 2026

Inducing Dendritic Growth in Cultured Sympathetic Neurons
09:52

Inducing Dendritic Growth in Cultured Sympathetic Neurons

Published on: March 21, 2012

12.6K
Time-lapse Live Imaging and Quantification of Fast Dendritic Branch Dynamics in Developing Drosophila Neurons
08:23

Time-lapse Live Imaging and Quantification of Fast Dendritic Branch Dynamics in Developing Drosophila Neurons

Published on: September 25, 2019

5.8K
Imaging Dendritic Spines in Caenorhabditis elegans
09:14

Imaging Dendritic Spines in Caenorhabditis elegans

Published on: September 27, 2021

2.3K

Main Results:

  • Dendrites of hippocampal pyramidal neurons generate diverse active calcium signals in vivo.
  • These signals show distinct spatial patterns and temporal dynamics.
  • Active dendritic calcium events are prevalent during naturalistic behaviors.

Conclusions:

  • Active dendritic calcium signaling is a fundamental aspect of hippocampal pyramidal neuron function in live animals.
  • These findings challenge previous assumptions based on slice physiology and highlight the importance of in vivo studies.
  • Dendritic integration of active calcium signals likely plays a key role in hippocampal information processing.