Related Experiment Video
Updated: May 1, 2026
A Murine Tail Lymphedema Model
Published on: February 10, 2021
An open-label study to evaluate sildenafil for the treatment of lymphatic malformations
Christina Danial1, Andrea L Tichy1, Umar Tariq2
1Department of Dermatology, Lucile Packard Children's Hospital at the Stanford University School of Medicine, Palo Alto, California.
Background:
Lymphatic malformations can be challenging to treat. Mainstay interventions including surgery and sclerotherapy are invasive and can result in local recurrence and complications.
Objective:
We sought to assess the effect of 20 weeks of oral sildenafil on reducing lymphatic malformation volume and symptoms in children.
Methods:
Seven children (4 boys, 3 girls; ages 13-85 months) with lymphatic malformations were given oral sildenafil for 20 weeks in this open-label study. The volume of the lymphatic malformation was calculated blindly using magnetic resonance imaging performed before and after 20 weeks of sildenafil. Lymphatic malformations were assessed clinically on weeks 4, 12, 20, and 32. Both the physician and parents evaluated the lymphatic malformation in comparison with baseline.
Results:
Four subjects had a lymphatic malformation volume decrease (1.0%-31.7%). In 2 subjects, despite a lymphatic malformation volume increase (1.1%-3.7%), clinical improvement was noted while on sildenafil. One subject had a 29.6% increase in lymphatic malformation volume and no therapeutic response. Lymphatic malformations of all 6 subjects who experienced a therapeutic response on sildenafil softened and became easily compressible. Adverse events were minimal.
Limitations:
A randomized controlled trial will be necessary to verify the effects of sildenafil on lymphatic malformations.
Conclusions:
Sildenafil can reduce lymphatic malformation volume and symptoms in some children.
