Related Experiment Video

Updated: May 1, 2026

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

3.2K

Abnormal levels of expression of plasma microRNA-33 in patients with psoriasis

S García-Rodríguez1, S Arias-Santiago2, J Orgaz-Molina3

  • 1Departamento de Biología Celular e Inmunología, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN, Consejo Superior de Investigaciones Científicas (CSIC), Parque Tecnológico Ciencias de la Salud, Armilla, Granada, España.

Actas Dermo-Sifiliograficas
|March 25, 2014
PubMed
Abstract

Insights

Plasma levels of microRNA-33 (miRNA-33), linked to lipid metabolism, are elevated in patients with plaque psoriasis and correlate with insulin. This finding may offer new insights into psoriasis-related systemic inflammation.

Area of Science:

  • Biochemistry
  • Genetics
  • Dermatology

Background:

  • Circulating microRNAs (miRNAs) regulate genes involved in lipid metabolism (miRNA-33) and vascular function (miRNA-126).
  • Plaque psoriasis is associated with systemic inflammation and cardiovascular risk factors.

Purpose of the Study:

  • To measure plasma levels of miRNA-33 and miRNA-126 in plaque psoriasis patients.
  • To evaluate the association of these miRNAs with clinical parameters and cardiovascular risk.

Main Methods:

  • Quantitative real-time polymerase chain reaction was used to analyze plasma miRNA levels in 11 plaque psoriasis patients and 11 healthy controls.
  • Cardiovascular risk factors and subclinical carotid atheromatosis were assessed.

Main Results:

  • Psoriasis patients exhibited significantly higher plasma miRNA-33 levels compared to controls (P=.0049).
  • A positive correlation was found between miRNA-33 and insulin levels in patients (r=0.7289, P=.0109).
  • No significant differences in miRNA-126 levels were observed between groups, though a negative correlation with carotid intima-media thickness was noted in patients (r=-0.6181, P=.0426).

Conclusions:

  • Elevated plasma miRNA-33 levels in psoriasis patients suggest a role in lipid and glucose metabolism dysregulation.
  • Circulating miRNA-33 may serve as a biomarker for systemic inflammatory abnormalities associated with psoriasis.
Keywords:
Carotid intima-media thicknessInsulinInsulinaMedia del grosor de la íntima carotídeaPsoriasismiARN-126miARN-33miRNA-126miRNA-33

More Related Videos

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.1K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.1K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.2K