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Updated: May 1, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Cerebrospinal fluid IL-1β correlates with cortical pathology load in multiple sclerosis at clinical onset
Dario Seppi1, Marco Puthenparampil1, Lisa Federle1
1Multiple Sclerosis Centre of Padova, Department of Neurosciences, University of Padova, via Giustiniani 2, 35128 Padova, Italy.
Abstract:
The cerebrospinal fluid levels of interleukin-1 beta and structural magnetic resonance parameters of cortical damage, i.e., cortical lesion number and volume, and global cortical thickness, were analysed in multiple sclerosis patients at clinical onset. Cerebrospinal fluid interleukin-1 beta levels strongly correlated with cortical lesion load and cortical thickness, while correlation with white matter lesion load was modest. Interleukin-1 beta, intrathecally produced by infiltrating lymphocytes and activated microglia, may constitute a possible link between inflammation and neurodegeneration in multiple sclerosis.
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