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Gene expression changes in chronic inflammatory demyelinating polyneuropathy skin biopsies
Stefania Puttini1, Petrica-Adrian Panaite2, Nicolas Mermod3
1Department of Clinical Neurosciences, Nerve-Muscle Unit, Lausanne University Hospital (CHUV), rue du Bugnon 46, CH-1011 Lausanne, Switzerland; Institute of Biotechnology, University of Lausanne (UNIL), chemin des Alambiques, CH-1015 Lausanne, Switzerland.
Abstract:
Chronic-inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated disease with no known biomarkers for diagnosing the disease or assessing its prognosis. We performed transcriptional profiling microarray analysis on skin punch biopsies from 20 CIDP patients and 17 healthy controls to identify disease-associated gene expression changes. We demonstrate changes in expression of genes involved in immune and chemokine regulation, growth and repair. We also found a combination of two upregulated genes that can be proposed as a novel biomarker of the disorder.
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